---
title: Scientists Can Now See What AI Models Learn From Raw DNA
description: A method called PISA traces a model's prediction at any single DNA base back to every other base behind it, exposing when the model has learned the quirks of...
author: Darie Nani (Editor-in-Chief)
date: 2026-08-26T13:30:00.000Z
updated: 2026-08-26T19:15:30.214Z
canonical: https://www.sovereignmagazine.com/article/pisa-ai-models-read-dna-genomics
image: https://cdn.nanimediahouse.com/pisa-genomic-ai-dna-207684.webp
categories: science & tech
content_type: News
region: Global
publication: Rich Health Magazine
access: members
schema_type: Article
---

A team of researchers has developed a way to look inside the artificial intelligence models that read raw DNA, and to tell when one of those models has learned something real about biology rather than a quirk of how the data was made.

The method is called PISA, short for Pairwise Influence by Sequence Attribution. It was published in Nature Communications in August 2026 by a group led by Charles McAnany, an AI Fellow at the Stowers Institute for Medical Research in Kansas City, Missouri, with senior author Julia Zeitlinger, an investigator at Stowers, and collaborator Anshul Kundaje of Stanford University. The same collaboration produced BPNet, a 2021 framework for base-resolution genomic deep learning, and PISA ships as part of a software toolkit the group maintains called BPReveal.

## PISA maps every base against every prediction

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